||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-ABCG5 (350-450) is suitable for use in Western Blot.
||PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ABCG5 (NP_071881.1).
| Tissue Specificity || Strongly expressed in the liver, lower levels in the small intestine and colon. |
| Post Translational Modifications || N-glycosylated. |
| Function || ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity. |
| Protein Name || Atp-Binding Cassette Sub-Family G Member 5Sterolin-1 |
| Database Links || Reactome: R-HSA-1369062Reactome: R-HSA-5679090Reactome: R-HSA-5679096Reactome: R-HSA-9029569 |
| Cellular Localisation || Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names || Anti-Atp-Binding Cassette Sub-Family G Member 5 antibodyAnti-Sterolin-1 antibodyAnti-ABCG5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance