Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Lysosomal cobalamin transporter ABCD4 (111-160 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ABCD4 |
Gene ID: | 5826 |
Uniprot ID: | ABCD4_HUMAN |
Immunogen Region: | 111-160 aa |
Specificity: | ABCD4 Polyclonal Antibody detects endogenous levels of ABCD4 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human ABCD4 at the amino acid range 111-160 |
Function | Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane. |
Protein Name | Lysosomal Cobalamin Transporter Abcd4 Atp-Binding Cassette Sub-Family D Member 4 Pmp70-Related Protein P70r Peroxisomal Membrane Protein 1-Like Pxmp1-L Peroxisomal Membrane Protein 69 Pmp69 |
Database Links | Reactome: R-HSA-5683329 Reactome: R-HSA-9758881 Reactome: R-HSA-9758890 |
Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Lysosome Membrane Targeted By Lmbrd1 Lysosomal Chaperone To The Lysosomal Membrane |
Alternative Antibody Names | Anti-Lysosomal Cobalamin Transporter Abcd4 antibody Anti-Atp-Binding Cassette Sub-Family D Member 4 antibody Anti-Pmp70-Related Protein antibody Anti-P70r antibody Anti-Peroxisomal Membrane Protein 1-Like antibody Anti-Pxmp1-L antibody Anti-Peroxisomal Membrane Protein 69 antibody Anti-Pmp69 antibody Anti-ABCD4 antibody Anti-PXMP1L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance