• Western Blot analysis of HEK293 lysis, using primary antibody at 1:1000 dilution. Secondary antibody (STJS000791) was diluted at 1:10000

Anti-ABCC6 antibody (290-370 aa) (STJ190991)

SKU:
STJ190991

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP-binding cassette sub-family C member 6 (290-370 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCC6
Gene ID: 368
Uniprot ID: MRP6_HUMAN
Immunogen Region: 290-370 aa
Specificity: MRP6 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 290-370
Post Translational Modifications Glycosylated.
Function Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.
Protein Name Atp-Binding Cassette Sub-Family C Member 6
Anthracycline Resistance-Associated Protein
Multi-Specific Organic Anion Transporter E
Moat-E
Multidrug Resistance-Associated Protein 6
Database Links Reactome: R-HSA-382556
Reactome: R-HSA-5690338
Cellular Localisation Basal Cell Membrane
Multi-Pass Membrane Protein
Localized To The Basal Membrane Of Sertoli Cells
Isoform 1: Basolateral Cell Membrane
Isoform 2: Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 6 antibody
Anti-Anthracycline Resistance-Associated Protein antibody
Anti-Multi-Specific Organic Anion Transporter E antibody
Anti-Moat-E antibody
Anti-Multidrug Resistance-Associated Protein 6 antibody
Anti-ABCC6 antibody
Anti-ARA antibody
Anti-MRP6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance