| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCC10 (1400-1492) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCC10 |
| Gene ID: |
89845 |
| Uniprot ID: |
MRP7_HUMAN |
| Immunogen Region: |
1400-1492 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1400-1492 of human ABCC10 (NP_001185863.1). |
| Immunogen Sequence: |
AKILCIDEATASVDQKTDQL LQQTICKRFANKTVLTIAHR LNTILNSDRVLVLQAGRVVE LDSPATLRNQPHSLFQQLLQ SSQQGVPASLGGP |
| Tissue Specificity | In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells, moderately in the adluminal compartment of the seminiferous tubules, and in vascular endothelial cells. Isoform 1: Specifically expressed in spleen. Isoform 2: Widely expressed. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 10Multidrug Resistance-Associated Protein 7 |
| Database Links | Reactome: R-HSA-382556 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneBasal Cell MembraneLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 10 antibodyAnti-Multidrug Resistance-Associated Protein 7 antibodyAnti-ABCC10 antibodyAnti-MRP7 antibodyAnti-SIMRP7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
