Host: |
Rabbit |
Applications: |
IF |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit monoclonal antibody anti-Phospholipid-Transporting Atpase Abca1 (1170-1350) is suitable for use in Immunofluorescence research applications. |
Clonality: |
Monoclonal |
Clone ID: |
S4627RM |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
IF/ICC 1:50-1:200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
ABCA1 |
Gene ID: |
19 |
Uniprot ID: |
ABCA1_HUMAN |
Immunogen Region: |
1170-1350 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1170-1350 of human ABCA1 (NP_005493.2). |
Immunogen Sequence: |
DHESDTLTIDVSAISNLIRK HVSEARLVEDIGHELTYVLP YEAAKEGAFVELFHEIDDRL SDLGISSYGISETTLEEIFL KVAEESGVDAETSDGTLPAR RNRRAFGDKQSCLRPFTEDD AADPNDSDIDPESRETDLLS GMDGKGSYQVKGWKLTQQQF VALLWKRLLIARRSRKGFFA Q |
Tissue Specificity | Widely expressed, but most abundant in macrophages. |
Post Translational Modifications | Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane. |
Function | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain. |
Protein Name | Phospholipid-Transporting Atpase Abca1Atp-Binding Cassette Sub-Family A Member 1Atp-Binding Cassette Transporter 1Abc-1Atp-Binding Cassette 1Cholesterol Efflux Regulatory Protein |
Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-5682113Reactome: R-HSA-8963896Reactome: R-HSA-9029569 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome |
Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Abca1 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 1 antibodyAnti-Atp-Binding Cassette Transporter 1 antibodyAnti-Abc-1 antibodyAnti-Atp-Binding Cassette 1 antibodyAnti-Cholesterol Efflux Regulatory Protein antibodyAnti-ABCA1 antibodyAnti-ABC1 antibodyAnti-CERP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance