| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ADCY6 Positive Control for STJ502058 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Adcy6 |
| Gene ID: |
25289 |
| Uniprot ID: |
ADCY6_RAT |
| Specificity: |
This is positive control is recommended for use in combination with ADCY6 antibody STJ502058. |
| Tissue Specificity | Detected in brain and kidney. Detected in vascular smooth muscle cells. |
| Post Translational Modifications | Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA on Ser-660 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC on Ser-554, Ser-660 and Thr-917 inhibits catalytic activity. |
| Function | Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli. |
| Peptide Name | Adenylate Cyclase Type 6Atp Pyrophosphate-Lyase 6Adenylate Cyclase Type ViAcviAdenylyl Cyclase 6Ac6Ca(2+-Inhibitable Adenylyl Cyclase |
| Database Links | Reactome: R-RNO-163615Reactome: -RNO-170660Reactome: -RNO-170670Reactome: -RNO-400042Reactome: -RNO-418597Reactome: -RNO-5610787 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumStereocilium |
| Alternative Peptide Names | Adenylate Cyclase Type 6 proteinAtp Pyrophosphate-Lyase 6 proteinAdenylate Cyclase Type Vi proteinAcvi proteinAdenylyl Cyclase 6 proteinAc6 proteinCa(2+-Inhibitable Adenylyl Cyclase proteinAdcy6 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
