| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ZDHHC9 Blocking Peptide for STJ503571 is synthetically produced from the 250-300 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
ZDHHC9 |
| Gene ID: |
51114 |
| Uniprot ID: |
ZDHC9_HUMAN |
| Immunogen Region: |
250-300 |
| Specificity: |
This blocking peptide is recommended for use in combination with ZDHHC9 antibody, STJ503571 |
| Immunogen: |
Synthetic peptide taken within amino acid region 250-300 on human Palmitoyltransferase ZDHHC9 protein. |
| Tissue Specificity | Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes. |
| Function | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (Probable). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. |
| Peptide Name | Palmitoyltransferase Zdhhc9Zinc Finger Dhhc Domain-Containing Protein 9Dhhc-9Dhhc9Zinc Finger Protein 379Zinc Finger Protein 380 |
| Database Links | Reactome: R-HSA-9648002Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Peptide Names | Palmitoyltransferase Zdhhc9 proteinZinc Finger Dhhc Domain-Containing Protein 9 proteinDhhc-9 proteinDhhc9 proteinZinc Finger Protein 379 proteinZinc Finger Protein 380 proteinZDHHC9 proteinCXorf11 proteinZDHHC10 proteinZNF379 proteinZNF380 proteinCGI-89 proteinUNQ261 proteinPRO298 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
