WEE2 Blocking Peptide for STJ503525 peptide (STJ505663)

SKU:
STJ505663-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: WEE2 Blocking Peptide for STJ503525 is synthetically produced from the 60-110 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Wee2
Gene ID: 381759
Uniprot ID: WEE2_MOUSE
Immunogen Region: 60-110
Specificity: This blocking peptide is recommended for use in combination with WEE2 antibody, STJ503525
Immunogen: Synthetic peptide taken within amino acid region 60-110 on mouse Wee1-like protein kinase isoform 2.
Post Translational Modifications Phosphorylated by PKA at Ser-15 in vitro, leading to activate kinase activity. Phosphorylation at Ser-15 by CaMK2, leading to increase its activity and promote metaphase II exit during egg activation.
Function Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Peptide Name Wee1-Like Protein Kinase 2
Wee1-Like Protein Kinase 1b
Wee1b Kinase
Mwee1b
Cellular Localisation Cytoplasm
Nucleus
Localizes Mainly In The Nucleus
Exported From The Nucleus To The Cytoplasm Before Germinal Vesicle Breakdown (Gvbd)
Allowing Meiosis Resumption
Alternative Peptide Names Wee1-Like Protein Kinase 2 protein
Wee1-Like Protein Kinase 1b protein
Wee1b Kinase protein
Mwee1b protein
Wee2 protein
Wee1b protein

Information sourced from Uniprot.org

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