VPS26 Blocking Peptide peptide (STJ505062)

SKU:
STJ505062-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: VPS26 Blocking Peptide is synthetically produced from the 315-375 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: VPS26A
Gene ID: 9559
Uniprot ID: VP26A_HUMAN
Immunogen Region: 315-375
Immunogen: Synthetic peptide taken within amino acids 315-375 on human VPS26 protein.
Function Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2A (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins.
Peptide Name Vacuolar Protein Sorting-Associated Protein 26a
Vesicle Protein Sorting 26a
Hvps26
Database Links Reactome: R-HSA-3238698
Cellular Localisation Cytoplasm
Endosome Membrane
Peripheral Membrane Protein
Early Endosome
Localizes To Tubular Profiles Adjacent To Endosomes
Predominantly Found In Early Not Late Endosomes
Alternative Peptide Names Vacuolar Protein Sorting-Associated Protein 26a protein
Vesicle Protein Sorting 26a protein
Hvps26 protein
VPS26A protein
VPS26 protein

Information sourced from Uniprot.org

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