TRAF6 Blocking Peptide for STJ503382 peptide (STJ505031)

SKU:
STJ505031-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TRAF6 Blocking Peptide for STJ503382 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TRAF6
Gene ID: 7189
Uniprot ID: TRAF6_HUMAN
Specificity: This blocking peptide is recommended for use in combination with TRAF6 antibody, STJ503382
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on TRAF6 protein.
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Post Translational Modifications Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1. Polyubiquitinated on Lys-124 by TRAF3IP2.after cell stimulation with IL17A. Polyubiquitinated on Lys-124.after cell stimulation with IL1B or TGFB. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappaB signaling upon DNA damage. LRRC19 induces 'Lys-63' ubiquitination. Ubiquitinated at Lys-319 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. (Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1 on both 'Lys-48' and 'Lys-63'-linked ubiquitin chains.leading to NF-kappa-B signaling inhibition.
Function E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. Participates also in the TCR signaling by ubiquitinating LAT.
Peptide Name Tnf Receptor-Associated Factor 6
E3 Ubiquitin-Protein Ligase Traf6
Interleukin-1 Signal Transducer
Ring Finger Protein 85
Ring-Type E3 Ubiquitin Transferase Traf6
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-166058
Reactome: R-HSA-168638
Reactome: R-HSA-168927
Reactome: R-HSA-193692
Reactome: R-HSA-202424
Reactome: R-HSA-205043
Reactome: R-HSA-209543
Reactome: R-HSA-209560
Reactome: R-HSA-2871837
Reactome: R-HSA-445989
Reactome: R-HSA-450302
Reactome: R-HSA-450321
Reactome: R-HSA-5607764
Reactome: R-HSA-5689880
Reactome: R-HSA-5689896
Reactome: R-HSA-6811558
Reactome: R-HSA-9014325
Reactome: R-HSA-9020702
Reactome: R-HSA-933541
Reactome: R-HSA-933542
Reactome: R-HSA-937039
Reactome: R-HSA-937041
Reactome: R-HSA-937042
Reactome: R-HSA-937072
Reactome: R-HSA-9645460
Reactome: R-HSA-9692916
Reactome: R-HSA-9705671
Reactome: R-HSA-975110
Reactome: R-HSA-975138
Reactome: R-HSA-975144
Reactome: R-HSA-975155
Reactome: R-HSA-975163
Reactome: R-HSA-9758274
Reactome: R-HSA-975871
Cellular Localisation Cytoplasm
Cell Cortex
Nucleus
Lipid Droplet
Found In The Nuclei Of Some Aggressive B-Cell Lymphoma Cell Lines As Well As In The Nuclei Of Both Resting And Activated T- And B-Lymphocytes
Found In Punctate Nuclear Body Protein Complexes
Ubiquitination May Occur In The Cytoplasm And Sumoylation In The Nucleus
Rsad2/Viperin Recruits It To The Lipid Droplet
Alternative Peptide Names Tnf Receptor-Associated Factor 6 protein
E3 Ubiquitin-Protein Ligase Traf6 protein
Interleukin-1 Signal Transducer protein
Ring Finger Protein 85 protein
Ring-Type E3 Ubiquitin Transferase Traf6 protein
TRAF6 protein
RNF85 protein

Information sourced from Uniprot.org

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