• Rat YWHAz (Tyrosine 3/Tryptophan 5 Monooxygenase Activation Protein Zeta) Sandwich ELISA Kit (STJE0013139)

Rat YWHAz (Tyrosine 3/Tryptophan 5 Monooxygenase Activation Protein Zeta) Sandwich ELISA Kit (STJE0013139)

SKU:
STJE0013139

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This YWHAz Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Ywhaz
Gene ID: 25578
Uniprot ID: 1433Z_RAT
Sample Type: serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Highly expressed in brain (at protein level).
Post Translational Modifications The delta, brain-specific form differs from the zeta form in being phosphorylated. Phosphorylation on Ser-184 by MAPK8.promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232.inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA.disrupts homodimerization and heterodimerization with YHAE and TP53.
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity.
Protein Name 14-3-3 Protein Zeta/Delta
Mitochondrial Import Stimulation Factor S1 Subunit
Protein Kinase C Inhibitor Protein 1
Kcip-1
Database Links Reactome: R-RNO-111447
Reactome: -RNO-3769402
Reactome: -RNO-392517
Reactome: -RNO-430116
Reactome: -RNO-450604
Reactome: -RNO-512988
Reactome: -RNO-5625740
Reactome: -RNO-5628897
Reactome: -RNO-75035
Reactome: -RNO-9013700
Reactome: -RNO-9614399
Cellular Localisation Cytoplasm
Melanosome
Located To Stage I To Stage Iv Melanosomes
Alternative ELISA Names 14-3-3 Protein Zeta/Delta ELISA kit
Mitochondrial Import Stimulation Factor S1 Subunit ELISA kit
Protein Kinase C Inhibitor Protein 1 ELISA kit
Kcip-1 ELISA kit
Ywhaz ELISA kit
Msfs1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance