• Rat TFR (Transferrin Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0018883)

Rat TFR (Transferrin Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0018883)

SKU:
STJE0018883

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.236ng/mL
Detection Limit: 0.625-40ng/mL
Short Description: This TFR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Tfrc
Gene ID: 64678
Uniprot ID: TFR1_RAT
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity In testis, expressed in Sertoli cells, peritubular myoid cells and in germinal cells. Highest levels in Sertoli cells.
Post Translational Modifications Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation. Stearoylation does not affect iron uptake. N- and O-glycosylated, phosphorylated and palmitoylated.
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2.
Protein Name Transferrin Receptor Protein 1
Tr
Tfr
Tfr1
Trfr
Cd Antigen Cd71
Database Links Reactome: R-RNO-432722
Reactome: -RNO-8856825
Reactome: -RNO-8856828
Reactome: -RNO-8980692
Reactome: -RNO-9013026
Reactome: -RNO-9013106
Reactome: -RNO-9013149
Reactome: -RNO-9013404
Reactome: -RNO-9013406
Reactome: -RNO-9013407
Reactome: -RNO-9013408
Reactome: -RNO-9013423
Reactome: -RNO-917977
Reactome: -RNO-9696270
Reactome: -RNO-9696273
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Melanosome
Alternative ELISA Names Transferrin Receptor Protein 1 ELISA kit
Tr ELISA kit
Tfr ELISA kit
Tfr1 ELISA kit
Trfr ELISA kit
Cd Antigen Cd71 ELISA kit
Tfrc ELISA kit
Trfr ELISA kit
output

Information sourced from Uniprot.org

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