• Rat SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Ready-To-Use (STJE0018648)

Rat SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Ready-To-Use (STJE0018648)

SKU:
STJE0018648

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.124ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This SOCS2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Socs2
Gene ID: 84607
Uniprot ID: SOCS2_RAT
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Ubiquitinated.mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on phosphorylation at Ser-52, by PKC and is stimulated by LPS. Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation.
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Suppressor Of Cytokine Signaling 2
Socs-2
Cytokine-Inducible Sh2 Protein 2
Database Links Reactome: R-RNO-8951664
Reactome: -RNO-9706369
Cellular Localisation
Alternative ELISA Names Suppressor Of Cytokine Signaling 2 ELISA kit
Socs-2 ELISA kit
Cytokine-Inducible Sh2 Protein 2 ELISA kit
Socs2 ELISA kit
Cish2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance