• Rat SCNN1a (Amiloride Sensitive Sodium Channel Subunit Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0018428)

Rat SCNN1a (Amiloride Sensitive Sodium Channel Subunit Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0018428)

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STJE0018428

£513.50 - £705.50
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SCNN1a Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Scnn1a
Gene ID: 25122
Uniprot ID: SCNNA_RAT
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Detected in kidney, lung and testis (at protein level). In the testis, detected within the seminiferous tubules but not in the interstitial cells (at protein level).
Post Translational Modifications Ubiquitinated.this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. N-glycosylated.
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Protein Name Amiloride-Sensitive Sodium Channel Subunit Alpha
Alpha-Nach
Epithelial Na(+ Channel Subunit Alpha
Alpha-Enac
Nonvoltage-Gated Sodium Channel 1 Subunit Alpha
Scnea
Database Links Reactome: R-RNO-2672351
Reactome: -RNO-9730628
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Cilium
Cytoplasmic Granule
Cytoplasm
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Flagellum
In Multi-Ciliated Cells
Located On Cilia
In Non-Ciliated Epithelial Cells
Restricted To Apical Surfaces
In Epidermis
Located Nearly Uniformly In The Cytoplasm In A Granular Distribution
In Sebaceous Glands
Observed Only In The Cytoplasmic Space In Between The Lipid Vesicles
In Eccrine Sweat Glands
Mainly Located At The Apical Surface Of The Cells Facing The Lumen
In Skin
In Arrector Pili Muscle Cells And In Adipocytes
Located In The Cytoplasm And Colocalized With Actin Fibers
In Spermatogonia
Spermatocytes And Round Spermatids
Located In The Cytoplasm
Prior To Spermiation
Location Shifts From The Cytoplasm To The Spermatid Tail
In Spermatozoa
Localizes At The Acrosome And The Central Region Of The Sperm Flagellum
Alternative ELISA Names Amiloride-Sensitive Sodium Channel Subunit Alpha ELISA kit
Alpha-Nach ELISA kit
Epithelial Na(+ Channel Subunit Alpha ELISA kit
Alpha-Enac ELISA kit
Nonvoltage-Gated Sodium Channel 1 Subunit Alpha ELISA kit
Scnea ELISA kit
Scnn1a ELISA kit
Renac ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance