| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
12.4pg/mL |
| Detection Limit: |
31.2-2000pg/mL |
| Short Description: |
This PST Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Sult1a1 |
| Gene ID: |
83783 |
| Uniprot ID: |
ST1A1_RAT |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Liver, kidney, heart and colon. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important roles in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. |
| Protein Name | Sulfotransferase 1a1St1a1Aryl SulfotransferaseAryl Sulfotransferase IvAstivMinoxidil SulfotransferaseMx-StPst-1Phenol SulfotransferaseSulfokinaseTyrosine-Ester Sulfotransferase |
| Database Links | Reactome: R-RNO-156584Reactome: -RNO-9753281 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Sulfotransferase 1a1 ELISA kitSt1a1 ELISA kitAryl Sulfotransferase ELISA kitAryl Sulfotransferase Iv ELISA kitAstiv ELISA kitMinoxidil Sulfotransferase ELISA kitMx-St ELISA kitPst-1 ELISA kitPhenol Sulfotransferase ELISA kitSulfokinase ELISA kitTyrosine-Ester Sulfotransferase ELISA kitSult1a1 ELISA kitSt1a1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
