| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
27ng/mL |
| Detection Limit: |
78.1-5000ng/mL |
| Short Description: |
This Plg Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Plg |
| Gene ID: |
85253 |
| Uniprot ID: |
PLMN_RAT |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | In the presence of the inhibitor, the activation involves only cleavage after Arg-581, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide. |
| Function | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. |
| Protein Name | Plasminogen Cleaved Into - Plasmin Heavy Chain A - Activation Peptide - Angiostatin - Plasmin Heavy Chain A - Short Form - Plasmin Light Chain B |
| Database Links | Reactome: R-RNO-114608Reactome: -RNO-1592389Reactome: -RNO-186797Reactome: -RNO-381426Reactome: -RNO-75205Reactome: -RNO-8964041 |
| Cellular Localisation | SecretedLocates To The Cell Surface Where It Is Proteolytically Cleaved To Produce The Active PlasminInteraction With Hrg Tethers It To The Cell Surface |
| Alternative ELISA Names | Plasminogen Cleaved Into - Plasmin Heavy Chain A - Activation Peptide - Angiostatin - Plasmin Heavy Chain A - Short Form - Plasmin Light Chain B ELISA kitPlg ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
