• Rat OX (Orexin) Sandwich ELISA Kit (STJE0011225)

Rat OX (Orexin) Sandwich ELISA Kit (STJE0011225)

SKU:
STJE0011225

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 6.7pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This OX Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Hcrt
Gene ID: 25723
Uniprot ID: OREX_RAT
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Mainly expressed in the brain, with expression in neurons in the dorsal lateral hypothalamic area (at protein level). Produced by a small group of neurons restricted to the lateral and posterior hypothalamus and perifornical areas. Positive neurons project widely throughout the entire neuroaxis. Particularly abundant projections in the cerebral cortex, olfactory bulb, hippocampus, amygdala, septum, diagonal band of Broca, bed nucleus of the stria terminalis, thalamus, anterior and posterior hypothalamus, midbrain, brainstem, and spinal cord. Also expressed in the enteric nervous system and pancreas. In small amount, also detected in the testis.
Post Translational Modifications Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function. Orexin-A: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Orexin-B: Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner.
Protein Name Hypocretin Neuropeptide Precursor
Hypocretin
Hcrt
Orexin Precursor
Prepro-Orexin
Preprohypocretin Cleaved Into - Orexin-A
Hypocretin-1
Hcrt1 - Orexin-B
Hypocretin-2
Hcrt2
Database Links Reactome: R-RNO-389397
Reactome: -RNO-416476
Cellular Localisation Rough Endoplasmic Reticulum
Cytoplasmic Vesicle
Synapse
Associated With Perikaryal Rough Endoplasmic Reticulum As Well As Cytoplasmic Large Granular Vesicles At Synapses
Alternative ELISA Names Hypocretin Neuropeptide Precursor ELISA kit
Hypocretin ELISA kit
Hcrt ELISA kit
Orexin Precursor ELISA kit
Prepro-Orexin ELISA kit
Preprohypocretin Cleaved Into - Orexin-A ELISA kit
Hypocretin-1 ELISA kit
Hcrt1 - Orexin-B ELISA kit
Hypocretin-2 ELISA kit
Hcrt2 ELISA kit
Hcrt ELISA kit
Ox ELISA kit
Ppox ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance