| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.062ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This NRG2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Nrg2 |
| Gene ID: |
432361 |
| Uniprot ID: |
NRG2_RAT |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in most parts of the brain, especially the olfactory bulb and cerebellum where it localizes in granule and Purkinje cells. In the hippocampus, found in the granule cells of the dentate gyrus. In the basal forebrain, found in the cholinergic cells. In the hindbrain, weakly detectable in the motor trigeminal nucleus. Not detected in the hypothalamus. Also found in the liver and in the thymus. Not detected in heart, adrenal gland, or testis. |
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. |
| Function | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
| Protein Name | Pro-Neuregulin-2 - Membrane-Bound IsoformPro-Nrg2 Cleaved Into - Neuregulin-2Nrg-2Neural- And Thymus-Derived Activator For Erbb KinasesNtak |
| Database Links | Reactome: R-RNO-1227986Reactome: -RNO-1236394Reactome: -RNO-1250196Reactome: -RNO-1250342Reactome: -RNO-1250347Reactome: -RNO-1257604Reactome: -RNO-1306955Reactome: -RNO-1358803Reactome: -RNO-1963640Reactome: -RNO-1963642Reactome: -RNO-5673001Reactome: -RNO-6785631Reactome: -RNO-6811558Reactome: -RNO-8847993Reactome: -RNO-8863795 |
| Cellular Localisation | Pro-Neuregulin-2Membrane-Bound Isoform: Cell MembraneSingle-Pass Type I Membrane ProteinDoes Not Seem To Be ActiveNeuregulin-2: Secreted |
| Alternative ELISA Names | Pro-Neuregulin-2 - Membrane-Bound Isoform ELISA kitPro-Nrg2 Cleaved Into - Neuregulin-2 ELISA kitNrg-2 ELISA kitNeural- And Thymus-Derived Activator For Erbb Kinases ELISA kitNtak ELISA kitNrg2 ELISA kitNtak ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
