• Rat NRG1 (Neuregulin 1) Sandwich ELISA Kit Ready-To-Use (STJE0017467)

Rat NRG1 (Neuregulin 1) Sandwich ELISA Kit Ready-To-Use (STJE0017467)

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STJE0017467

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.225ng/mL
Detection Limit: 0.625-40ng/mL
Short Description: This NRG1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Nrg1Uniprot ID=NRG1_RAT"
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Widely expressed. Most tissues contain isoform alpha2A and isoform alpha2B. Isoform Alpha2 and isoform beta2 are the predominant forms in mesenchymal and non-neuronal organs. Isoform Beta1 is enriched in brain and spinal cord, but not in muscle and heart. Isoform Alpha2C is highly expressed in spinal cord, moderately in lung, brain, ovary, and stomach, in low amounts in the kidney, skin and heart and not detected in the liver, spleen, and placenta.
Post Translational Modifications Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage.
Function Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells.inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction.stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells.stimulating Schwann cell proliferation.implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons.
Protein Name Pro-Neuregulin-1 - Membrane-Bound Isoform
Pro-Nrg1 Cleaved Into - Neuregulin-1
Acetylcholine Receptor-Inducing Activity
Aria
Glial Growth Factor
Heregulin
Hrg
Neu Differentiation Factor
Sensory And Motor Neuron-Derived Factor
Database Links
Cellular Localisation Pro-Neuregulin-1
Membrane-Bound Isoform: Cell Membrane
Single-Pass Type I Membrane Protein
Does Not Seem To Be Active
Neuregulin-1: Secreted
Alternative ELISA Names Pro-Neuregulin-1 - Membrane-Bound Isoform ELISA kit
Pro-Nrg1 Cleaved Into - Neuregulin-1 ELISA kit
Acetylcholine Receptor-Inducing Activity ELISA kit
Aria ELISA kit
Glial Growth Factor ELISA kit
Heregulin ELISA kit
Hrg ELISA kit
Neu Differentiation Factor ELISA kit
Sensory And Motor Neuron-Derived Factor ELISA kit
Nrg1 ELISA kit
Ndf ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance