• Rat LAT (Linker For Activation Of T-Cell) Sandwich ELISA Kit Ready-To-Use (STJE0016655)

Rat LAT (Linker For Activation Of T-Cell) Sandwich ELISA Kit Ready-To-Use (STJE0016655)

SKU:
STJE0016655

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.036ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This LAT Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Lat
Gene ID: 81511
Uniprot ID: LAT_RAT
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Expressed in NK cells. Present in lymph node, spleen and thymus (at protein level).
Post Translational Modifications Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation.which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Palmitoylation of Cys-27 and Cys-30 is required for raft targeting and efficient phosphorylation. Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation.which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. 'Lys-63'-linked ubiquitinated by TRAF6.
Function Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Protein Name Linker For Activation Of T-Cells Family Member 1
36 Kda Phosphotyrosine Adapter Protein
Pp36
P36-38
Database Links Reactome: R-RNO-114604
Reactome: -RNO-202433
Reactome: -RNO-2424491
Reactome: -RNO-2454202
Reactome: -RNO-2871796
Reactome: -RNO-2871809
Reactome: -RNO-5673001
Cellular Localisation Cell Membrane
Single-Pass Type Iii Membrane Protein
Present In Lipid Rafts
Alternative ELISA Names Linker For Activation Of T-Cells Family Member 1 ELISA kit
36 Kda Phosphotyrosine Adapter Protein ELISA kit
Pp36 ELISA kit
P36-38 ELISA kit
Lat ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance