| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
11.5pg/mL |
| Detection Limit: |
31.2-2000pg/mL |
| Short Description: |
This IP10 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Cxcl10 |
| Gene ID: |
245920 |
| Uniprot ID: |
CXL10_RAT |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | In the central nervous system, CXCL10 is predominantly localized to activated neurons. Expressed in both microglia and astrocytes. |
| Post Translational Modifications | |
| Function | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization. |
| Protein Name | C-X-C Motif Chemokine 1010 Kda Interferon Gamma-Induced ProteinGamma-Ip10Ip-10Interferon-Inducible Protein 10Protein Mob-1Small-Inducible Cytokine B10 |
| Database Links | Reactome: R-RNO-380108Reactome: -RNO-418594 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | C-X-C Motif Chemokine 10 ELISA kit10 Kda Interferon Gamma-Induced Protein ELISA kitGamma-Ip10 ELISA kitIp-10 ELISA kitInterferon-Inducible Protein 10 ELISA kitProtein Mob-1 ELISA kitSmall-Inducible Cytokine B10 ELISA kitCxcl10 ELISA kitInp10 ELISA kitMob1 ELISA kitScyb10 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
