| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.069ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This GRIN2A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
Grin2a |
| Gene ID: |
24409 |
| Uniprot ID: |
NMDE1_RAT |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Detected in brain cortex, olfactory bulb, hippocampus including the dentate gyrus, striatum, thalamus, superior colliculus, inferior colliculus, midbrain and cerebellum (at protein level). Detected in brain cortex, hypothalamus and cerebellum. |
| Post Translational Modifications | |
| Function | Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2aGlun2aGlutamate Nmda Receptor Subunit Epsilon-1N-Methyl D-Aspartate Receptor Subtype 2aNmdar2aNr2a |
| Database Links | Reactome: R-RNO-438066Reactome: -RNO-8849932Reactome: -RNO-9609736 |
| Cellular Localisation | Cell ProjectionDendritic SpineCell MembraneMulti-Pass Membrane ProteinSynapsePostsynaptic Cell MembraneCytoplasmic Vesicle MembraneExpression At The Dendrite Cell Membrane And At Synapses Is Regulated By Sorcs2 And The Retromer Complex |
| Alternative ELISA Names | Glutamate Receptor Ionotropic - Nmda 2a ELISA kitGlun2a ELISA kitGlutamate Nmda Receptor Subunit Epsilon-1 ELISA kitN-Methyl D-Aspartate Receptor Subtype 2a ELISA kitNmdar2a ELISA kitNr2a ELISA kitGrin2a ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
