| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.65ng/mL |
| Detection Limit: |
1.56-100ng/mL |
| Short Description: |
This FGb Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Tissue Specificity | |
| Post Translational Modifications | Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. |
| Function | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. |
| Protein Name | Fibrinogen Beta ChainLiver Regeneration-Related Protein Lrrg036/Lrrg043/Lrrg189 Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain |
| Database Links | Reactome: R-RNO-114608Reactome: -RNO-140875Reactome: -RNO-216083Reactome: -RNO-354192Reactome: -RNO-354194Reactome: -RNO-372708Reactome: -RNO-5674135 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Fibrinogen Beta Chain ELISA kitLiver Regeneration-Related Protein Lrrg036/Lrrg043/Lrrg189 Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain ELISA kitFgb ELISA kitAb1-181 ELISA kitAb1-216 ELISA kitAc1-581 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
