| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.24ng/mL |
| Detection Limit: |
0.781-50ng/mL |
| Short Description: |
This DIO2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Dio2 |
| Gene ID: |
65162 |
| Uniprot ID: |
IOD2_RAT |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in cerebral cortex, cerebellum, pituitary gland, mostly in anterior pituitary gland, and pineal gland, as well as in brown adipose tissue (BAT). |
| Post Translational Modifications | Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33. |
| Function | Catalyzes the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. |
| Protein Name | Type Ii Iodothyronine Deiodinase5diiDioiiType 2 DiType-Ii 5'-Deiodinase |
| Database Links | Reactome: R-RNO-350864 |
| Cellular Localisation | MembraneSingle-Pass Membrane Protein |
| Alternative ELISA Names | Type Ii Iodothyronine Deiodinase ELISA kit5dii ELISA kitDioii ELISA kitType 2 Di ELISA kitType-Ii 5'-Deiodinase ELISA kitDio2 ELISA kitItdi2 ELISA kitTxdi2 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
