• Rat ATP2B2 (ATPase, Ca++ Transporting, Plasma Membrane 2) Sandwich ELISA Kit (STJE0007388)

Rat ATP2B2 (ATPase, Ca++ Transporting, Plasma Membrane 2) Sandwich ELISA Kit (STJE0007388)

SKU:
STJE0007388

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ATP2B2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Atp2b2
Gene ID: 24215
Uniprot ID: AT2B2_RAT
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Isoforms containing segment B are found in brain, uterus, liver and kidney and in low levels in other tissues. Isoforms containing segment W are found in kidney, uterus, and pancreas. Isoforms containing segment Y are found in pancreas and in low levels in brain and heart. Isoforms containing segment Z are found in brain and heart and isoforms containing segment X are found in low levels in brain. Isoforms containing segment A are found in low levels in heart and small intestine while isoforms containing segment C are found in testis and in low levels in other tissues.
Post Translational Modifications
Function ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk.
Protein Name Plasma Membrane Calcium-Transporting Atpase 2
Pmca2
Plasma Membrane Calcium Atpase Isoform 2
Plasma Membrane Calcium Pump Isoform 2
Database Links Reactome: R-RNO-418359 P11506-2
Reactome: -RNO-5578775 P11506-2
Reactome: -RNO-936837 P11506-2
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Synapse
Apical Cell Membrane
Basolateral Cell Membrane
Alternative ELISA Names Plasma Membrane Calcium-Transporting Atpase 2 ELISA kit
Pmca2 ELISA kit
Plasma Membrane Calcium Atpase Isoform 2 ELISA kit
Plasma Membrane Calcium Pump Isoform 2 ELISA kit
Atp2b2 ELISA kit
output

Information sourced from Uniprot.org

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