| Applications: |
ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.064ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This ARHGEF7 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Arhgef7 |
| Gene ID: |
114559 |
| Uniprot ID: |
ARHG7_RAT |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Phosphorylated on Ser-516 by CaMK1.enhancement of GEF activity and downstream activation of RAC1. Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 7Beta-PixPak-Interacting Exchange Factor Beta |
| Database Links | Reactome: R-RNO-182971Reactome: -RNO-193648Reactome: -RNO-3928664Reactome: -RNO-416482Reactome: -RNO-8980692Reactome: -RNO-9013149Reactome: -RNO-9013406Reactome: -RNO-9013420Reactome: -RNO-9013424 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell ProjectionRuffleCytoplasmCell CortexLamellipodiumDetected At Cell AdhesionsA Small Proportion Is Detected At Focal Adhesions |
| Alternative ELISA Names | Rho Guanine Nucleotide Exchange Factor 7 ELISA kitBeta-Pix ELISA kitPak-Interacting Exchange Factor Beta ELISA kitArhgef7 ELISA kitPak3bp ELISA kitPixb ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
