• Rat ANGPTL4 (Angiopoietin Like Protein 4) Sandwich ELISA Kit (STJE0007151)

Rat ANGPTL4 (Angiopoietin Like Protein 4) Sandwich ELISA Kit (STJE0007151)

SKU:
STJE0007151

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.61ng/mL
Detection Limit: 1.56-100ng/mL
Short Description: This ANGPTL4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Angptl4
Gene ID: 362850
Uniprot ID: ANGL4_RAT
Sample Type: serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications N-glycosylated. ANGPTL4 N-terminal chain: Forms disulfide-linked dimers and tetramers. Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain.both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell.
Function Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis. ANGPTL4 N-terminal chain: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.
Protein Name Angiopoietin-Related Protein 4
Angiopoietin-Like Protein 4
Hepatic Fibrinogen/Angiopoietin-Related Protein
Hfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain
Database Links Reactome: R-RNO-8963889
Reactome: -RNO-9762292
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
The Unprocessed Form Interacts With The Extracellular Matrix
This May Constitute A Dynamic Reservoir
A Regulatory Mechanism Of The Bioavailability Of Angptl4
Alternative ELISA Names Angiopoietin-Related Protein 4 ELISA kit
Angiopoietin-Like Protein 4 ELISA kit
Hepatic Fibrinogen/Angiopoietin-Related Protein ELISA kit
Hfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain ELISA kit
Angptl4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance