• Rat ADAMTS4 (A Disintegrin And Metalloproteinase With Thrombospondin 4) Sandwich ELISA Kit Ready-To-Use (STJE0013278)

Rat ADAMTS4 (A Disintegrin And Metalloproteinase With Thrombospondin 4) Sandwich ELISA Kit Ready-To-Use (STJE0013278)

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STJE0013278

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 1.15ng/mL
Detection Limit: 3.12-200ng/mL
Short Description: This ADAMTS4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Adamts4
Gene ID: 66015
Uniprot ID: ATS4_RAT
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Brain specific.
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Protein Name A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4
Adam-Ts 4
Adam-Ts4
Adamts-4
Aggrecanase-1
Database Links Reactome: R-RNO-1474228
Reactome: -RNO-5173214
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative ELISA Names A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 ELISA kit
Adam-Ts 4 ELISA kit
Adam-Ts4 ELISA kit
Adamts-4 ELISA kit
Aggrecanase-1 ELISA kit
Adamts4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance