• Rat ADAM10 (A Disintegrin And Metalloprotease 10) Sandwich ELISA Kit Ready-To-Use (STJE0013261)

Rat ADAM10 (A Disintegrin And Metalloprotease 10) Sandwich ELISA Kit Ready-To-Use (STJE0013261)

SKU:
STJE0013261

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 27pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This ADAM10 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Adam10
Gene ID: 29650
Uniprot ID: ADA10_RAT
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in brain, kidney, lung, spleen, ovary and testis.
Post Translational Modifications The precursor is cleaved by furin and PCSK7.
Function Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA. Enhances the cleavage of CHL1 by BACE1. Cleaves NRCAM. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain. Involved in the development and maturation of glomerular and coronary vasculature. During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions. May regulate the EFNA5-EPHA3 signaling.
Protein Name Disintegrin And Metalloproteinase Domain-Containing Protein 10
Adam 10
Kuzbanian Protein Homolog
Mammalian Disintegrin-Metalloprotease
Cd Antigen Cd156c
Database Links Reactome: R-RNO-1474228
Reactome: -RNO-381426
Reactome: -RNO-6798695
Reactome: -RNO-8957275
Reactome: -RNO-9013507
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus Membrane
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Cell Projection
Axon
Dendrite
Cell Junction
Adherens Junction
Cytoplasm
Is Localized In The Plasma Membrane But Is Also Expressed In The Golgi Apparatus And In Clathrin-Coated Vesicles Derived Likely From The Golgi
During Long Term Depression
It Is Recruited To The Cell Membrane By Dlg1
The Immature Form Is Mainly Located Near Cytoplasmic Fibrillar Structures
While The Mature Form Is Predominantly Located At Zonula Adherens And The Cell Membrane
The Localization And Clustering Of Mature Adam10 To Zonula Adherens Is Regulated By Afdn
Tspan33
Plekha7 And Pdzd11
Alternative ELISA Names Disintegrin And Metalloproteinase Domain-Containing Protein 10 ELISA kit
Adam 10 ELISA kit
Kuzbanian Protein Homolog ELISA kit
Mammalian Disintegrin-Metalloprotease ELISA kit
Cd Antigen Cd156c ELISA kit
Adam10 ELISA kit
Madm ELISA kit
output

Information sourced from Uniprot.org

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