| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PTBP1 Blocking Peptide for STJ506092 is synthetically produced from the 150-200 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PTBP1 |
| Gene ID: |
5725 |
| Uniprot ID: |
PTBP1_HUMAN |
| Immunogen Region: |
150-200 |
| Specificity: |
This blocking peptide is recommended for use in combination with PTBP1 antibody, STJ506092 |
| Immunogen: |
Synthetic peptide corresponding to amino acids within region 150-200 on human Polypyrimidine tract-binding protein 1. |
| Function | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. |
| Peptide Name | Polypyrimidine Tract-Binding Protein 1Ptb57 Kda Rna-Binding Protein Pptb-1Heterogeneous Nuclear Ribonucleoprotein IHnrnp I |
| Database Links | Reactome: R-HSA-6803529Reactome: R-HSA-72163Reactome: R-HSA-72203 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Polypyrimidine Tract-Binding Protein 1 proteinPtb protein57 Kda Rna-Binding Protein Pptb-1 proteinHeterogeneous Nuclear Ribonucleoprotein I proteinHnrnp I proteinPTBP1 proteinPTB protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
