| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.072ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This Viperin Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Rsad2 |
| Gene ID: |
58185 |
| Uniprot ID: |
RSAD2_MOUSE |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed at higher levels in atherosclerotic arteries than in normal arteries. |
| Post Translational Modifications | Acetylated by HAT1. HAT1-mediated acetylation of Lys-198 in turn recruits UBE4A that stimulates RSAD2 polyubiquitination leading to proteasomal degradation. 'Lys-6'-linked polyubiquitination at Lys-207 leads to RSAD2 protein degradation. |
| Function | Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. |
| Protein Name | S-Adenosylmethionine-Dependent Nucleotide Dehydratase Rsad2SandRadical S-Adenosyl Methionine Domain-Containing Protein 2Virus Inhibitory Protein - Endoplasmic Reticulum-Associated - Interferon-InducibleViperin |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideGolgi ApparatusEndoplasmic ReticulumLipid DropletMitochondrionMitochondrion Inner MembraneMitochondrion Outer Membrane |
| Alternative ELISA Names | S-Adenosylmethionine-Dependent Nucleotide Dehydratase Rsad2 ELISA kitSand ELISA kitRadical S-Adenosyl Methionine Domain-Containing Protein 2 ELISA kitVirus Inhibitory Protein - Endoplasmic Reticulum-Associated - Interferon-Inducible ELISA kitViperin ELISA kitRsad2 ELISA kitVig1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
