Mouse VEGFA protein (Recombinant-Active) (N-His) (STJP012058)

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STJP012058-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Mouse VEGFA-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: Vegfa
Gene ID: 22339
Uniprot ID: VEGFA_MOUSE
Immunogen Region: Ala27-Leu190
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Vascular endothelial growth factor A, long form: Produced by use of an alternative upstream CUG codon and post-translationally processed into the N-terminal N-VEGF form and the C-terminal secreted VEGFA form.
Function N-VEGF: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A. Involved in protecting cells from hypoxia-mediated cell death. VEGFA: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis.
Protein Name Vascular Endothelial Growth Factor A - Long Form
L-Vegf
Vascular Permeability Factor
Vpf Cleaved Into - N-Vegf - Vegfa
Database Links Reactome: R-MMU-114608
Reactome: -MMU-194313
Reactome: -MMU-195399
Reactome: -MMU-4420097
Reactome: -MMU-5218921
Cellular Localisation N-Vegf: Cytoplasm
Nucleus
Cytoplasmic In Normoxic Conditions And Localizes To The Nucleus Under Hypoxic Conditions
Vegfa: Secreted
Isoform L-Vegf-2: Endoplasmic Reticulum
Golgi Apparatus
Secreted
Extracellular Space
Extracellular Matrix
Isoform Vegf-1: Secreted
Isoform Vegf-2: Secreted
Isoform Vegf-3: Cell Membrane
Peripheral Membrane Protein
Remains Cell-Surface Associated Unless Released By Heparin
Alternative Protein Names Vascular Endothelial Growth Factor A - Long Form protein
L-Vegf protein
Vascular Permeability Factor protein
Vpf Cleaved Into - N-Vegf - Vegfa protein
Vegfa protein
Vegf protein

Information sourced from Uniprot.org

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