Mouse VEGF-A (Vascular Endothelial Growth Factor A-Long Form) Antibody Pair (STJAP00085)

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STJAP00085-50
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Host: Goat/Goat
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This VEGF-A antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Polyclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: Vegfa
Gene ID: 22339
Uniprot ID: VEGFA_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse VEGF-A protein.
Detection Immunogen: Recombinant Mouse VEGF-A protein.
Post Translational Modifications Vascular endothelial growth factor A, long form: Produced by use of an alternative upstream CUG codon and post-translationally processed into the N-terminal N-VEGF form and the C-terminal secreted VEGFA form.
Function N-VEGF: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A. Involved in protecting cells from hypoxia-mediated cell death. VEGFA: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis.
Protein Name Vascular Endothelial Growth Factor A - Long Form
L-Vegf
Vascular Permeability Factor
Vpf Cleaved Into - N-Vegf - Vegfa
Database Links Reactome: R-MMU-114608
Reactome: -MMU-194313
Reactome: -MMU-195399
Reactome: -MMU-4420097
Reactome: -MMU-5218921
Cellular Localisation N-Vegf: Cytoplasm
Nucleus
Cytoplasmic In Normoxic Conditions And Localizes To The Nucleus Under Hypoxic Conditions
Vegfa: Secreted
Isoform L-Vegf-2: Endoplasmic Reticulum
Golgi Apparatus
Secreted
Extracellular Space
Extracellular Matrix
Isoform Vegf-1: Secreted
Isoform Vegf-2: Secreted
Isoform Vegf-3: Cell Membrane
Peripheral Membrane Protein
Remains Cell-Surface Associated Unless Released By Heparin
Alternative Antibody Pair Names Vascular Endothelial Growth Factor A - Long Form antibody pair
L-Vegf antibody pair
Vascular Permeability Factor antibody pair
Vpf Cleaved Into - N-Vegf - Vegfa antibody pair
Vegfa antibody pair
Vegf antibody pair

Information sourced from Uniprot.org

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