| Host: |
HEK293 Cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse TNFSF12/TWEAK-C-raFc protein was developed from hek293 cells and has a target region of C-raFc. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is typically 10-50 ng/mL. |
| Gene Symbol: |
Tnfsf12 |
| Gene ID: |
21944 |
| Uniprot ID: |
TNF12_MOUSE |
| Immunogen Region: |
Arg105-His249 |
| Immunogen: |
Recombinant Mouse TNFSF12/TWEAK Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Arg105-His249) of mouse TNFSF12/TWEAK (Accession #NP_035744.1) fused with a raFc tag at the C-terminus. |
| Post Translational Modifications | The soluble form is produced from the membrane form by proteolytic processing. |
| Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 12Tnf-Related Weak Inducer Of ApoptosisTweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form |
| Database Links | Reactome: R-MMU-5668541Reactome: -MMU-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 12Secreted Form: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 12 proteinTnf-Related Weak Inducer Of Apoptosis proteinTweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form proteinTnfsf12 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
