• Mouse TLR6 (Toll Like Receptor 6) Sandwich ELISA Kit (STJE0012640)

Mouse TLR6 (Toll Like Receptor 6) Sandwich ELISA Kit (STJE0012640)

SKU:
STJE0012640

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.125ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This TLR6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Tlr6
Gene ID: 21899
Uniprot ID: TLR6_MOUSE
Sample Type: tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Detected in thymus, spleen, ovary and lung. Expressed in macrohpages.
Post Translational Modifications
Function Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
Protein Name Toll-Like Receptor 6
Cd Antigen Cd286
Database Links Reactome: R-MMU-5686938
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasmic Vesicle
Phagosome Membrane
Membrane Raft
Golgi Apparatus
Upon Complex Formation With Cd36 And Tlr4
Internalized Through Dynamin-Dependent Endocytosis
Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand
In Response To Diacylated Lipoproteins
Tlr2:Tlr6 Heterodimers Are Recruited In Lipid Rafts
This Recruitment Determine The Intracellular Targeting To The Golgi Apparatus
Alternative ELISA Names Toll-Like Receptor 6 ELISA kit
Cd Antigen Cd286 ELISA kit
Tlr6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance