| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.105ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This TGFbR2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Tgfbr2 |
| Gene ID: |
21813 |
| Uniprot ID: |
TGFR2_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus. |
| Post Translational Modifications | Phosphorylated on a Ser/Thr residue in the cytoplasmic domain. |
| Function | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Isoform RII-1: Has transforming growth factor beta-activated receptor activity. Isoform RII-2: Has transforming growth factor beta-activated receptor activity. |
| Protein Name | Tgf-Beta Receptor Type-2Tgfr-2Tgf-Beta Type Ii ReceptorTransforming Growth Factor-Beta Receptor Type IiTgf-Beta Receptor Type IiTbetar-Ii |
| Database Links | Reactome: R-MMU-2173788Reactome: -MMU-2173789Reactome: -MMU-2173791 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative ELISA Names | Tgf-Beta Receptor Type-2 ELISA kitTgfr-2 ELISA kitTgf-Beta Type Ii Receptor ELISA kitTransforming Growth Factor-Beta Receptor Type Ii ELISA kitTgf-Beta Receptor Type Ii ELISA kitTbetar-Ii ELISA kitTgfbr2 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
