• Mouse SORT1 (Sortilin 1) Sandwich ELISA Kit (STJE0012278)

Mouse SORT1 (Sortilin 1) Sandwich ELISA Kit (STJE0012278)

SKU:
STJE0012278

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.066ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SORT1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Sort1
Gene ID: 20661
Uniprot ID: SORT_MOUSE
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in the brain, particularly the piriform cortex, the cerebral cortex and the hippocampus.
Post Translational Modifications The N-terminal propeptide is cleaved by furin and possibly other homologous proteases. Phosphorylation at Ser-819 facilitates the interaction with GGA1. Palmitoylated. Undergoes cysteine S-palmitoylation which promotes the partitioning of the receptor into an endosomal membrane subdomain where it can interact with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus.
Function Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
Protein Name Sortilin
Neurotensin Receptor 3
Ntr3
Mntr3
Database Links Reactome: R-MMU-432722
Cellular Localisation Golgi Apparatus
Golgi Stack Membrane
Single-Pass Type I Membrane Protein
Endosome Membrane
Endoplasmic Reticulum Membrane
Nucleus Membrane
Cell Membrane
Extracellular Side
Lysosome Membrane
Localized To Membranes Of The Endoplasmic Reticulum
Endosomes
Golgi Stack
Lysosomes And Nucleus
A Small Fraction Of The Protein Is Also Localized To The Plasma Membrane
May Also Be Found In Slc2a4/Glut4 Storage Vesicles (Gsvs) In Adipocytes
Localization To The Plasma Membrane In Adipocytes May Be Enhanced By Insulin
Alternative ELISA Names Sortilin ELISA kit
Neurotensin Receptor 3 ELISA kit
Ntr3 ELISA kit
Mntr3 ELISA kit
Sort1 ELISA kit
output

Information sourced from Uniprot.org

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