• Mouse SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit (STJE0012260)

Mouse SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit (STJE0012260)

SKU:
STJE0012260

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.066ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SOCS2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Socs2
Gene ID: 216233
Uniprot ID: SOCS2_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed primarily in the testis, some expression in liver and lung.
Post Translational Modifications Ubiquitinated.mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on phosphorylation at Ser-52, by PKC and is stimulated by LPS. Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation.
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Suppressor Of Cytokine Signaling 2
Socs-2
Cytokine-Inducible Sh2 Protein 2
Cis-2
Database Links Reactome: R-MMU-8951664
Reactome: -MMU-9706369
Cellular Localisation
Alternative ELISA Names Suppressor Of Cytokine Signaling 2 ELISA kit
Socs-2 ELISA kit
Cytokine-Inducible Sh2 Protein 2 ELISA kit
Cis-2 ELISA kit
Socs2 ELISA kit
Cis2 ELISA kit
Cish2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance