| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.085ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This SIAL2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Neu2 |
| Gene ID: |
23956 |
| Uniprot ID: |
NEUR2_MOUSE |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Highly expressed in heart. |
| Post Translational Modifications | |
| Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes exclusively monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward isomer alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues. |
| Protein Name | Sialidase-2Cytosolic SialidaseMouse Skeletal Muscle SialidaseMssMurine Thymic SialidaseMtsN-Acetyl-Alpha-Neuraminidase 2 |
| Database Links | Reactome: R-MMU-1660662Reactome: -MMU-4085001 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative ELISA Names | Sialidase-2 ELISA kitCytosolic Sialidase ELISA kitMouse Skeletal Muscle Sialidase ELISA kitMss ELISA kitMurine Thymic Sialidase ELISA kitMts ELISA kitN-Acetyl-Alpha-Neuraminidase 2 ELISA kitNeu2 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
