| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
6.3pg/mL |
| Detection Limit: |
15.6-1000pg/mL |
| Short Description: |
This REG3a Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Reg3a |
| Gene ID: |
19694 |
| Uniprot ID: |
REG3A_MOUSE |
| Sample Type: |
serum, plasma or other biological fluids. |
| Tissue Specificity | Small intestine and pancreas. |
| Post Translational Modifications | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. |
| Function | Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation. |
| Protein Name | Regenerating Islet-Derived Protein 3-AlphaReg-3-AlphaIslet Of Langerhans Regenerating Protein 3Lithostathine 3Pancreatitis-Associated Protein 2Regenerating Islet-Derived Protein Iii-AlphaReg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form |
| Database Links | Reactome: R-MMU-6803157 |
| Cellular Localisation | SecretedFound In The Apical Region Of Pancreatic Acinar Cells |
| Alternative ELISA Names | Regenerating Islet-Derived Protein 3-Alpha ELISA kitReg-3-Alpha ELISA kitIslet Of Langerhans Regenerating Protein 3 ELISA kitLithostathine 3 ELISA kitPancreatitis-Associated Protein 2 ELISA kitRegenerating Islet-Derived Protein Iii-Alpha ELISA kitReg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form ELISA kitReg3a ELISA kitPap2 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
