• Mouse RAB5A (RAB5A, Member RAS Oncogene Family) Sandwich ELISA Kit (STJE0011803)

Mouse RAB5A (RAB5A, Member RAS Oncogene Family) Sandwich ELISA Kit (STJE0011803)

SKU:
STJE0011803

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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.062ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This RAB5A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Rab5a
Gene ID: 271457
Uniprot ID: RAB5A_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.
Function Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
Protein Name Ras-Related Protein Rab-5a
Database Links Reactome: R-MMU-1660499
Reactome: -MMU-8856828
Reactome: -MMU-8873719
Reactome: -MMU-8876198
Reactome: -MMU-983231
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Early Endosome Membrane
Melanosome
Cytoplasmic Vesicle
Cell Projection
Ruffle
Membrane
Cytoplasm
Cytosol
Phagosome Membrane
Endosome Membrane
Enriched In Stage I Melanosomes
Alternates Between Membrane-Bound And Cytosolic Forms
Alternative ELISA Names Ras-Related Protein Rab-5a ELISA kit
Rab5a ELISA kit
nnyRab5a ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance