• Mouse Prostaglandin-H2 D-isomerase/PTGDS protein (Recombinant) (C-His) (STJP002479)

Mouse Prostaglandin-H2 D-isomerase/PTGDS protein (Recombinant) (C-His) (STJP002479)

SKU:
STJP002479-100

£500.50
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Host: HEK293 Cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse Prostaglandin-H2 D-isomerase/PTGDS-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Ptgds
Gene ID: 19215
Uniprot ID: PTGDS_MOUSE
Immunogen Region: Met1-Glu189
Immunogen: Recombinant Mouse Prostaglandin-H2 D-isomerase/PTGDS Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Met1-Glu189) of mouse Prostaglandin-H2 D-isomerase/PTGDS (Accession #NP_032989.2) fused with a
Function Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR.
Protein Name Prostaglandin-H2 D-Isomerase
Glutathione-Independent Pgd Synthase
Lipocalin-Type Prostaglandin-D Synthase
Prostaglandin-D2 Synthase
L-Pgds
Pgd2 Synthase
Pgds2
Database Links Reactome: R-MMU-2162123
Cellular Localisation Rough Endoplasmic Reticulum
Nucleus Membrane
Golgi Apparatus
Cytoplasm
Perinuclear Region
Secreted
Detected On Rough Endoplasmic Reticulum Of Arachnoid And Menigioma Cells
Localized To The Nuclear Envelope
Secretory Vesicles And Spherical Cytoplasmic Structures In Arachnoid Trabecular Cells
And To Circular Cytoplasmic Structures In Meningeal Macrophages And Perivascular Microglial Cells
In Oligodendrocytes
Localized To The Rough Endoplasmic Reticulum And Nuclear Envelope
In Retinal Pigment Epithelial Cells
Localized To Distinct Cytoplasmic Domains Including The Perinuclear Region
Also Secreted
Alternative Protein Names Prostaglandin-H2 D-Isomerase protein
Glutathione-Independent Pgd Synthase protein
Lipocalin-Type Prostaglandin-D Synthase protein
Prostaglandin-D2 Synthase protein
L-Pgds protein
Pgd2 Synthase protein
Pgds2 protein
Ptgds protein

Information sourced from Uniprot.org

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