| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
4.75pg/mL |
| Detection Limit: |
15.6-1000pg/mL |
| Short Description: |
This NMB Competitive ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
2.5 hrs |
| Gene Symbol: |
Nmb |
| Gene ID: |
68039 |
| Uniprot ID: |
NMB_MOUSE |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
serum, plasma or other biological fluids. |
| Tissue Specificity | In the hindbrain, expressed in the medulla surrounding the lateral half of the facial nucleus. Also expressed in the olfactory bulb and hippocampus. Detected in a subset of neurons distributed throughout the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG). Within the RTN/pFRG, expressed in neuronal subpopulations distinct from those expressing Grp. Expressed in lung. |
| Post Translational Modifications | |
| Function | Stimulates smooth muscle contraction. Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity. Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem. These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneeze reflex. Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons. Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation. Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6. Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R. |
| Protein Name | Neuromedin-B Cleaved Into - Neuromedin-B-32 - Neuromedin-B |
| Database Links | Reactome: R-MMU-375276Reactome: -MMU-416476 |
| Cellular Localisation | SecretedCell ProjectionNeuron ProjectionIn Neurons Of The Retrotrapezoid Nucleus//Parafacial Respiratory GroupExpressed On Neuron Projections Which Project Into The Pre-Botzinger Complex |
| Alternative ELISA Names | Neuromedin-B Cleaved Into - Neuromedin-B-32 - Neuromedin-B ELISA kitNmb ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
