Mouse LGMN/Legumain protein (Recombinant) (N-His) (STJP008685)

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STJP008685
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse LGMN/Legumain-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Lgmn
Gene ID: 19141
Uniprot ID: LGMN_MOUSE
Immunogen Region: Val18-Tyr435
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Glycosylated. Activated by autocatalytic processing at pH 4.
Function Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Protein Name Legumain
Protease - Cysteine 1
Database Links Reactome: R-MMU-1679131
Reactome: -MMU-2132295
Cellular Localisation Lysosome
Alternative Protein Names Legumain protein
Protease - Cysteine 1 protein
Lgmn protein
Prsc1 protein

Information sourced from Uniprot.org

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