| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
30pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This KIBRA Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
Wwc1 |
| Gene ID: |
211652 |
| Uniprot ID: |
KIBRA_MOUSE |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Mammary epithelium. |
| Post Translational Modifications | Phosphorylation at Ser-542 and Ser-923 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B. |
| Function | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking. |
| Protein Name | Protein KibraKidney And Brain ProteinKibraWw Domain-Containing Protein 1 |
| Database Links | Reactome: R-MMU-2028269 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusCell ProjectionRuffle MembraneColocalizes With Prkcz In The Perinuclear Region |
| Alternative ELISA Names | Protein Kibra ELISA kitKidney And Brain Protein ELISA kitKibra ELISA kitWw Domain-Containing Protein 1 ELISA kitWwc1 ELISA kitKiaa0869 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
