| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.118ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This ITGa3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Itga3 |
| Gene ID: |
16400 |
| Uniprot ID: |
ITA3_MOUSE |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in heart and brain. Only isoform 1 is detected in lung. |
| Post Translational Modifications | |
| Function | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. |
| Protein Name | Integrin Alpha-3Cd49 Antigen-Like Family Member CGalactoprotein B3Gapb3Vla-3 Subunit AlphaCd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain |
| Database Links | Reactome: R-MMU-216083Reactome: -MMU-8874081 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLipid-AnchorCell ProjectionInvadopodium MembraneFilopodium MembraneEnriched Preferentially At InvadopodiaCell Membrane Protrusions That Correspond To Sites Of Cell InvasionIn A Collagen-Dependent Manner |
| Alternative ELISA Names | Integrin Alpha-3 ELISA kitCd49 Antigen-Like Family Member C ELISA kitGalactoprotein B3 ELISA kitGapb3 ELISA kitVla-3 Subunit Alpha ELISA kitCd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain ELISA kitItga3 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
