Mouse IL4R protein (Recombinant) (C-6His) (STJP002879)

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STJP002879
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Immunoreactivity: Measured by its ability to inhibit the mIL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 0.5-2 Mu g/mL in the presence of 5 ng/mL of recombinant mouse IL-4.
Gene Symbol: Il4r
Gene ID: 16190
Uniprot ID: IL4RA_MOUSE
Immunogen Region: Ile 26-Arg 233
Immunogen: Recombinant Mouse IL4R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile 26-Arg 233) of mouse IL4R (Accession #NP_001008700.1) fused with and a 6×His tag at the C-terminus.
Immunogen Sequence: IKVLGEPTCFSDYIRTSTCE WFLDSAVDCSSQLCLHYRLM FFEFSENLTCIPRNSASTVC VCHMEMNRPVQSDRYQMELW AEHRQLWQGSFSPSGNVKPL APDNLTLHTNVSDEWLLTWN NLYPSNNLLYKDLISMVNIS REDNPAEFIVYNVTYKEPRL SFPINILMSGVYYTARVRVR SQILTGTWSEWSPSITWYNH FQLPLIQR
Post Translational Modifications On IL4 binding, phosphorylated on C-terminal tyrosine residues. Soluble IL4R can also be produced by proteolytic cleavage at the cell surface (shedding).
Function Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Protein Name Interleukin-4 Receptor Subunit Alpha
Il-4 Receptor Subunit Alpha
Il-4r Subunit Alpha
Il-4r-Alpha
Il-4ra
Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha
Soluble Il-4 Receptor Subunit Alpha
Soluble Il-4r-Alpha
Sil4ralpha/Prot
Il-4-Binding Protein
Il4-Bp
Database Links Reactome: R-MMU-6785807
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Protein Names Interleukin-4 Receptor Subunit Alpha protein
Il-4 Receptor Subunit Alpha protein
Il-4r Subunit Alpha protein
Il-4r-Alpha protein
Il-4ra protein
Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha protein
Soluble Il-4 Receptor Subunit Alpha protein
Soluble Il-4r-Alpha protein
Sil4ralpha/Prot protein
Il-4-Binding Protein protein
Il4-Bp protein
Il4r protein
Il4ra protein

Information sourced from Uniprot.org

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