| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse IFNAR1/IFN alpha/beta R1-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Endotoxin: |
Less than 1EU per Mu g by the LAL method. |
| Gene Symbol: |
Ifnar1 |
| Gene ID: |
15975 |
| Uniprot ID: |
INAR1_MOUSE |
| Immunogen Region: |
Glu27-Thr429 |
| Immunogen: |
Recombinant Mouse IFNAR1/IFN alpha/beta R1 Protein is expressed from Expi293 with hFc tag at the C-terminal.；It contains Glu27-Thr429. |
| Function | Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. |
| Protein Name | Interferon Alpha/Beta Receptor 1Ifn-R-1Ifn-Alpha/Beta Receptor 1Type I Interferon Receptor 1 |
| Database Links | Reactome: R-MMU-909733Reactome: -MMU-912694 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLate EndosomeLysosomeInterferon Binding Triggers Internalization Of The Receptor From The Cell Membrane Into Endosomes And Then Into Lysosomes |
| Alternative Protein Names | Interferon Alpha/Beta Receptor 1 proteinIfn-R-1 proteinIfn-Alpha/Beta Receptor 1 proteinType I Interferon Receptor 1 proteinIfnar1 proteinIfar proteinIfnar protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
