| Host: |
HEK293 cells |
| Reactivity: |
Mouse/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse & Human IL-12B & IL-23A-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Immobilized Human IL-23R alpha & Mouse IL-12, His at 0.5 Mu g/mL (100 Mu L/Well) on the plate. Dose response curve for Human IL23R, mFc with the EC50 of 0.36 Mu g/mL determined by ELISA. |
| Gene Symbol: |
IL23A |
| Gene ID: |
51561 |
| Uniprot ID: |
IL23A_HUMAN |
| Immunogen Region: |
Met23-Ser335 |
| Immunogen: |
Recombinant Human IL23 alpha & IL12 beta Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Met23-Ser335 (Mouse IL-12 beta) &Ile23-Ser328 (Human IL-23 alpha) ) of Human IL23 alpha & IL12 beta fused with a |
| Function | Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells. |
| Protein Name | Interleukin-23 Subunit AlphaIl-23 Subunit AlphaIl-23-AInterleukin-23 Subunit P19Il-23p19 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9020933 |
| Cellular Localisation | SecretedSecreted Upon Association With Il12b |
| Alternative Protein Names | Interleukin-23 Subunit Alpha proteinIl-23 Subunit Alpha proteinIl-23-A proteinInterleukin-23 Subunit P19 proteinIl-23p19 proteinIL23A proteinSGRF proteinUNQ2498 proteinPRO5798 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
