| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 6.0pg/mL |
| Detection Limit: | 15.6-1000pg/mL |
| Short Description: | This HBEGF Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Hbegf |
| Gene ID: | 15200 |
| Uniprot ID: | HBEGF_MOUSE |
| Sample Type: | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Most abundant in kidney, skeletal muscle, lung, spleen, brain and heart. |
| Post Translational Modifications | O-glycosylated. |
| Function | Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. |
| Protein Name | Proheparin-Binding Egf-Like Growth Factor Cleaved Into - Heparin-Binding Egf-Like Growth FactorHb-EgfHbegf |
| Database Links | Reactome: R-MMU-1227986Reactome: -MMU-1236394Reactome: -MMU-1250196Reactome: -MMU-1250342Reactome: -MMU-1250347Reactome: -MMU-1257604Reactome: -MMU-177929Reactome: -MMU-179812Reactome: -MMU-180292Reactome: -MMU-180336Reactome: -MMU-182971Reactome: -MMU-1963640Reactome: -MMU-1963642Reactome: -MMU-212718Reactome: -MMU-2179392Reactome: -MMU-5673001Reactome: -MMU-6785631Reactome: -MMU-6811558Reactome: -MMU-8847993Reactome: -MMU-8856825Reactome: -MMU-8856828Reactome: -MMU-8857538Reactome: -MMU-8863795Reactome: -MMU-9009391 |
| Cellular Localisation | Heparin-Binding Egf-Like Growth Factor: SecretedExtracellular SpaceMature Hb-Egf Is Released Into The Extracellular Space And Probably Binds To A ReceptorProheparin-Binding Egf-Like Growth Factor: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative ELISA Names | Proheparin-Binding Egf-Like Growth Factor Cleaved Into - Heparin-Binding Egf-Like Growth Factor ELISA kitHb-Egf ELISA kitHbegf ELISA kitHbegf ELISA kitDtr ELISA kitHegfl ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
